Schizophrenia
Conditions
Keywords
schizophrenia, rTMS
Brief summary
The study is a prospective, randomized, double-blind sham-controlled study.
Detailed description
The principal objective of this trial is to investigate the effect of left prefrontal high frequency rTMS on negative symptoms in schizophrenia.
Interventions
PROCEDURErTMS, repetitive transcranial magnetic stimulation
10 Hz rTMS (10.000 stimuli) over left dorsolateral prefrontal cortex
OTHERrTMS
repetitive transcranial magnetic stimulation, 10 Hz, 10.000 stimuli, 2 weeks
Sponsors
Heinrich-Heine University, Duesseldorf
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* DSM-IV criteria for schizophrenia * age between 18 and 60 * informed consent * right handed patient * no change of antipsychotic treatment \> 2 weeks before recruitment
Exclusion criteria
* seizures, epilepsy * history of severe head injury * status post implantation of a cardiac pacemaker or other electronic devi-ses
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Global Impression; | November 2007 |
Secondary
| Measure | Time frame |
|---|---|
| Global psychosocial functioning (GAF), PANSS-Negative Subscale,changes in EEG, heart rate variability, cortisol daytime profile, catecholamines, cognitive functioning | November 2007 |
Countries
Germany
Outcome results
None listed