Monoamine Oxidases in Smoking Pregnant Women and Newborns

Comparison of Monoamines Oxidases A and B Activities and the Metabolism of Nicotine in Smoking and Nonsmoking Pregnant Women and in Their Newborns. Evaluation of Their Effects on the Newborns' Behavior

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00169390

Enrollment

Registered

2005-09-15

Start date

2004-03-31

Completion date

2007-11-30

Last updated

2015-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Newborn, Pregnancy, Smoking

Keywords

smoking, pregnancy, newborns, monoamine oxidases

Brief summary

Smoking substantially inhibits the activities of both monamine oxidase (MAO) A and B enzymes. Aims of this study: to compare MAO activities and nicotine and cotinine in peripheral blood of smoking and nonsmoking pregnant women, in their placenta and in cord blood and relate them with the behavior of their newborns being observed during 48 hours after birth.

Detailed description

40 pregnant smoking and 40 pregnant nonsmoking women will be included at the end of the 2nd trimester. Assessments: smoking characteristics, plasma cotinine, DHPG, DOPAC, 5HIAA concentrations reflecting MAOA activity and platelet MAOB activity will be measured just after inclusion (end of 2nd trimester), just before delivery in venous maternal blood and just after delivery in cord blood. The newborns' behavior (wellbeing) will be assessed every 8 hour after birth for 2 days. Comparisons will be made between smoking and nonsmoking women and their newborns.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* pregnancy of 5 or 6 months * nonsmokers: lifetime smoking of less than 100 cigarettes; smokers: unable to stop smoking during the first 3 months of pregnancy; smoking at least 10 cigarettes/day.

Exclusion criteria

* pathological pregnancies * opioid dependence; alcoholism. * chronic psychiatric, hematological, neurological disorders * eclampsia * chronic antidepressant or neuroleptic treatment * current nicotine replacement therapies

Design outcomes

Primary

Measure	Time frame
monoamine oxidase markers	at birth

Outcome results