Parkinson's Disease
Conditions
Keywords
Parkinson's disease, parkin mutation, Juvenile parkinson's disease, positron emission tomography
Brief summary
Parkinson's disease is a frequent neurodegenerative disorder. Genetic forms of the disease have been recently identified. The monogenic form due to parkin mutation is responsible for many familial cases and sporadic forms. However, the relationship between the mutation and the genotype of patients is not fully established. The aim of this study is to compare clinical, metabolic and neuropsychological characteristics obtained in patients with parkin mutation with those of patients without parkin mutation.
Interventions
DEVICEpositron emission tomography
Sponsors
University Hospital, Tours
Groupe Hospitalier Pitie-Salpetriere
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Juvenile Parkinson's disease (\< 45 years) * Parkin mutation * Normal brain magnetic resonance imaging (MRI)
Exclusion criteria
* Contraindication to brain MRI * Women without effective contraception
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological evaluation | — |
| Psychiatric evaluation | — |
| Parkin mutation | — |
| Motor disability | — |
Secondary
| Measure | Time frame |
|---|---|
| Positron emission tomography | — |
Countries
France
Contacts
Primary ContactAlexis Brice, MD, PhD
Outcome results
None listed