Anemia, Malaria
Conditions
Keywords
Intermittent preventive treatment, IPTi, Malaria control, Ghana
Brief summary
\- intermittent preventive treatment with SP in children to evaluate efficacy and safety of this drug combination in children in northern Ghana
Detailed description
* Sulfadoxine and pyrimethamine have long been used for malaria prevention and treatment. In this study, following suggestions of WHO, these drugs are used for intermittent treatment. * It will be tested if this approach reduces the number of malaria attacks and ameliorates the severity of the disease * It will also be determined if anemia due to malaria, which is prevalent in northern Ghana, may be reduced * Moreover, the interaction between red cell polymorphisms such as HbS, HbC, alpha-thalassemia and glucose-6-phosphate dehydrogenase deficiency and SP will be examined
Interventions
DRUGSulfadoxin (12.5) Pyrimethamine (250 mg)
Sponsors
Deutscher Akademischer Austausch Dienst
Charite University, Berlin, Germany
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
2 Months to 4 Months
Healthy volunteers
Yes
Inclusion criteria
* informed consent by parents or guardian * no concomitant serious disease * age \>2 months
Exclusion criteria
* serious allergy or hypersensitivity to sulfonamides or pyrimethamine * no severe hepatic or renal dysfunction * serious breach of study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy and safety of IPTi with SP | — |
| Impact of IPTi on incidence on malaria attacks | — |
| Impact of IPTi on anemia | — |
Secondary
| Measure | Time frame |
|---|---|
| Interaction between erythrocyte polymorphisms and SP | — |
| Influence on parasite multiplicity | — |
| Impact on child development | — |
Outcome results
None listed