Endotoxin Levels, TNF-alfa
Conditions
Keywords
Vitamin A, Endotoxin, TNF-alfa
Brief summary
Vitamin A given as treatment and pre-treatment has reduced the severity of symptoms after infusion with endotoxin in several animal models. We intend to examine the effect of vitamin A as pre-treatment on the response to endotoxin in humans. We furthermore wish to examine the long-term effects of vitamin A on the response to endotoxin. We hypothesise that vitamin A decreases endotoxin levels and TNF-alfa responses.
Detailed description
Vitamin A given as treatment and pre-treatment has reduced the severity of symptoms after infusion with endotoxin in several animal models. We intend to examine the effect of vitamin A as pre-treatment on the response to endotoxin in humans. As studies in children in low-income countries have indicated that vitamin A has long-term effects on the immune system, we furthermore wish to examine the long-term effects of vitamin A on the response to endotoxin. This will be done in an established model using infusion with endotoxin to male human volunteers. We hypothesise that vitamin A decreases endotoxin levels and TNF-alfa responses. Furthermore, we hypothesise that it reduces oxidative stress and injury.
Interventions
DRUGVitamin A
Sponsors
Uppsala University Hospital
Institute for Human Nutrition, Royal Veterinary School, Copenhagen, Denmark
Bandim Health Project
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
DOUBLE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy, male, between 18 and 35 years of age, non-smoker, no medicine, no infections in preceding 14 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endotoxin levels | — |
| TNF-alfa levels | — |
Secondary
| Measure | Time frame |
|---|---|
| Measures of oxidative injury and stress | — |
| Retinol and beta-caroten levels | — |
| Haematological values | — |
| Clinical markers | — |
Countries
Denmark
Outcome results
None listed