Peripheral Arterial Disease
Conditions
Brief summary
One important clinical challenge in older individuals is maintaining mobility in the absence of pain. Peripheral arterial disease affects up to 12% of adults over 50 and impairs quality of life due to intermittent claudication causing pain and limiting mobility. Conventional therapies have only modest effect in improving symptoms. The investigators hypothesise that angiotensin converting enzyme inhibition (with ramipril), which causes arterial vasodilation, also improves clinical symptoms in patients with peripheral arterial disease.
Interventions
DRUGRamipril
Sponsors
Baker Heart Research Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
No minimum to 70 Years
Healthy volunteers
No
Inclusion criteria
* Ankle-brachial index of \<0.9 at rest in at least one leg * History of intermittent claudication (unilateral or bilateral) which was stable for 6 months * Evidence of superficial femoral artery stenosis or occlusion on duplex scan * Blood pressure \<=160/90 mmHg * Stable medication regimen for at least 6 months and not previously treated with ACE inhibitors
Exclusion criteria
* Limiting coronary artery disease * Renal Failure * History of hypertension * History of type 2 diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to onset of claudication | — |
| Total exercise time during a standard treadmill test | — |
| Walking ability measured using the standard Walking Impairment Questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| Leg Blood Flow using Duplex Ultrasound | — |
Countries
Australia
Outcome results
None listed