Interstitial Lung Disease
Conditions
Keywords
Exercise, Pulmonary rehabilitation, Idiopathic pulmonary fibrosis, Connective tissue disorders
Brief summary
Interstitial lung disease (ILD) is a highly disabling group of conditions including idiopathic pulmonary fibrosis (IPF), acute and chronic interstitial pneumonias, connective tissue diseases and sarcoidosis. People with ILD frequently experience breathlessness on exertion, which limits their ability to undertake daily activities. People with ILD report very poor quality of life due to low levels of physical functioning and vitality, and high levels of breathlessness and fatigue. There are few treatments for ILD and those that are available have limited impact on quality of life. The aim of this study is to assess the effects of Pulmonary Rehabilitation, which consists of specialised exercise training for people with lung disease, on exercise capacity and quality of life in people with ILD. We hypothesis that exercise training will result in reduced dyspnoea, improved exercise tolerance and enhanced quality of life.
Detailed description
Interstitial lung disease (ILD) is a highly disabling group of conditions including idiopathic pulmonary fibrosis (IPF), acute and chronic interstitial pneumonias, connective tissue diseases and sarcoidosis. People with ILD frequently experience breathlessness on exertion, which limits their ability to undertake daily activities and reduces health-related quality of life.Available treatments for ILD have proved largely ineffective, offering no improvement in survival and demonstrating only limited impact on quality of life. Aims of the Research 1. Evaluate the effects of Pulmonary Rehabilitation on exercise capacity and quality of life in patients with ILD 2. Determine the physiological response to Pulmonary Rehabilitation in patients with ILD 3. Determine the relationship between the aetiology and severity of ILD and the effects of Pulmonary Rehabilitation. Comparisons: 8 weeks exercise training compared to control group (maximal exercise capacity, functional exercise capacity, dyspnoea, quality of life).
Interventions
BEHAVIORALPulmonary Rehabilitation
Sponsors
La Trobe University
Austin Hospital, Melbourne Australia
Victorian Tuberculosis and Lung Association
The Alfred
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
40 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Ambulant * Stable medical therapy * Dyspnoea on exertion following maximal treatment
Exclusion criteria
* A history of syncope on exertion * Too unwell to attend the hospital for exercise training * Any other comorbidities which would prevent exercise training * Previous Pulmonary Rehabilitation in the last 12 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional exercise capacity | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximal exercise capacity | — |
| Health-related quality of life | — |
| Dyspnoea | — |
Countries
Australia
Outcome results
None listed