Use of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in the Diagnosis of Pleural Effusion

Evaluation of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) as a Diagnostic Tool for Patients With Pleural Effusion

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00166894

Enrollment

100

Registered

2005-09-14

Start date

2005-05-31

Completion date

Unknown

Last updated

2005-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pleural Effusion

Keywords

pleural effusion, TREM-1

Brief summary

The aim of this trial is to evaluate the level of TREM-1 in different kinds of pleural effusion.

Detailed description

The triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily, and its expression is upregulated on phagocytic cells in the presence of bacteria or fungi. Several experiments by Bouchon and colleagues showed that TREM-1 mediates the acute inflammatory response to microbial products. Human tissues infected with bacteria are infiltrated with neutrophils and macrophages that express high levels of TREM-1. Conversely, TREM-1 is only weakly expressed in samples from patients with noninfectious inflammatory disorders. In addition, TREM-1 is shed from the membrane of activated phagocytes and can be found in a soluble form in body fluids. The presence of a soluble form of TREM-1 in samples of bronchoalveolar lavage fluid from mechanically ventilated patients has been shown to be a good indicator of infectious pneumonia.

Interventions

None listed

Study design

Observational model

NATURAL_HISTORY

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Minutes to No maximum

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of pleural effusion * Pleural effusion proved by chest sonography

Exclusion criteria

* Conditions for which thoracentesis are contraindicated * Pregnancy

Countries

Taiwan

Contacts

Primary ContactPan-Chyr Yang, MD, PhD

pcyang@ha.mc.ntu.edu.tw886-2-2356-2867

Outcome results