Melasma
Conditions
Keywords
Melasma, Jessner's solution, Trichloroacetic acid (TCA)
Brief summary
Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical peel involves applying the peeling agent to the skin for a short period. The skin will peel similar to a sunburn, and moisturizers are applied to the skin. Although both agents are well-accepted, there have been no good comparisons of the two agents. The purpose of this study is determine if there is a difference in the effectiveness of these two agents.
Interventions
PROCEDUREJessner's solution chemical peel
PROCEDURETrichloroacetic acid chemical peel
Sponsors
Emory University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults \> 18 years old * Clinical diagnosis of melasma * Mental capacity to give informed consent
Exclusion criteria
* Pregnancy * H/o allergy to Jessner's solution, tricholoracetetic acid, tretinoin, or hydroquinone * Active dermatitis * Presence of cutaneous infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical efficacy by clinician's evaluation | 3 months | Hyperpigmenation Global Score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy by subject's evaluation | 3 months | Hyperpigmentation Global Score |
Countries
United States
Outcome results
None listed