Prostate Cancer
Conditions
Keywords
MRI-guided bone marrow biopsy
Brief summary
The purpose of this study is to target lesions of the prostate in the bone and to biopsy these lesions using MRI to identify the areas.
Detailed description
* This study involves a one-time, MRI-guided bone marrow biopsy. Prior to this procedure, patients will need to have a bone scan performed within the last three months and a PSA blood test drawn within one month of registration to the study. * Patients are also required to participate in the DFCI research study Collection of Specimens and Clinical Data for Patients with Prostate Cancer or at High Risk for Prostate Cancer.
Interventions
PROCEDUREMagnetic Resonance Imaging
PROCEDUREBone Marrow Biopsy
Sponsors
Dana-Farber Cancer Institute
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
30 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Histologic diagnosis of prostate cancer * Bone scan consistent with or suspicious of metastatic prostate cancer within last three months * Platelet count \> 50,000/ul * PT and aPTT \< 1.5 x control * At least one week removed from taking aspirin or coumadin * Currently participating in protocol Collection of Specimens and Clinical Data for Patients with Prostate Cancer or at High Risk for Prostate Cancer
Exclusion criteria
* Devices incompatible to MR studies (e.g. pacemakers, ear implants, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the yield of detecting metastatic prostate cancer tissue using MRI-guided bone marrow needle biopsies to that of historical controls obtained through unguided biopsies. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the sensitivity of radiographic bone marrow changes detected by MRI for prostate cancer, as determined by the pathologic findings from bone marrow biopsy. | — |
Countries
United States
Outcome results
None listed