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Mindfulness Meditation in Bone Marrow Transplantation

Mindfulness Meditation in Bone Marrow Transplantation

Status
Completed
Phases
Phase 2Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00165282
Enrollment
241
Registered
2005-09-14
Start date
2005-04-30
Completion date
2011-06-30
Last updated
2013-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Marrow Transplantation, Hematologic Malignancy, Stem Cell Transplantation

Keywords

Meditation, Mindfulness meditation, Bone Marrow Transplant, Stem Cell Transplant

Brief summary

The main purpose of this study is to examine techniques to help patients cope better with the stem cell/bone marrow transplant procedure.

Detailed description

Patients will be assigned to one of three study groups: 1. receives the normal standard care; 2. meets with an oncology nurse educator, in addition to the regular nurses on the transplant team. The nurse educator will provide information and answers to patient's questions about the stem cell/bone marrow transplant experience; or 3. is taught mindfulness meditation by a nurse who is trained to be a mindfulness instructor and by an audio CD. Mindfulness meditation is a technique that may help in coping with the stress and difficulties associated with cancer and undergoing a stem cell/bone marrow transplant. It involves learning to be in the present moment by paying attention to your breathing, sights, and sounds, and to sensations you may be experiencing, or thoughts and feelings you may be having. Mindfulness meditation has been shown to be helpful to patients in the clinic who have cancer and other medical conditions. Patients, regardless of random group assignment, will complete a questionnaire 8 different times, from before they are admitted to the hospital until 6 months after discharge. Patients will also provide two urine samples while in the hospital to measure the levels of stress hormones present in the urine.

Interventions

BEHAVIORALMindfulness training

Taught mindfulness meditation by mindfulness instructor (trained health care professional/RN) and audio c/d

BEHAVIORALNurse education

Meets with oncology nurse to have questions answered about medical treatments and side effects

Sponsors

Dana-Farber Cancer Institute
CollaboratorOTHER
University of Massachusetts, Worcester
CollaboratorOTHER
Emory University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Autologous stem cell transplantation for hematologic malignancy * First transplant * 21 years of age or older * Speaks and understands English

Exclusion criteria

* Planned tandem (more than one) transplant * Taking corticosteroids on a regular basis for a chronic condition * Prior formal mindfulness meditation training * Significant cognitive impairment and/or confirmed psychosis or thought disorder

Design outcomes

Primary

MeasureTime frame
Psychological functioning1 year

Secondary

MeasureTime frame
Medication use1 year
Urinary stress hormones (cortisol and catecholamines)1 year
Transplant related complications1 year
Number of days to bone marrow engraftment1 year
Physical symptoms1 year
Quality of life1 year
Hospital length of stay and re-hospitalizations1 year

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026