Hodgkin's Disease
Conditions
Keywords
Hodgkin's Disease Stage IA-IIA, mantle irradiation
Brief summary
The purpose of this study it to evaluate the effectiveness of radiation therapy limited to above the diaphragm in patients with pathological stage IA-IIA Hodgkin's disease.
Detailed description
* Eligble patients will receive a course of radiation therapy directed to above the diaphragm only. * Patients would have bloodwork and chest x-rays performed 4 times per year for the first two years, 3 times per year for the third year, and 2 times per year for the fourth and fifth years. After five years, yearly check-ups are performed. * In addition to the above follow-up, patients will receive, once or twice a year for the first 5 years, an abdominal-pelvic CT scan and/or gallium scan.
Interventions
PROCEDUREMantle irradiation
Limited to above the diaphragm
Sponsors
Brigham and Women's Hospital
Massachusetts General Hospital
Dana-Farber Cancer Institute
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Pathologically Stage IA-IIA Hodgkin's disease * A negative staging laparotomy including splenectomy, biopsies of liver, paraortic nodal biopsies and palpitation of upper pelvic nodes * 18 years of age or older
Exclusion criteria
* Patients with large mediastinal adenopathy * Patients with LD histology * Patients with B symptoms * Positive laparotomy * Subcarinal, hilar, or cardiac lymph node involvement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the risks and benefits of mantle field irradiation alone in treating Hodgkin disease patients. | 5 years |
Countries
United States
Outcome results
None listed