Hip Fracture
Conditions
Keywords
Hip fracture, Rehabilitation, Transfusion, Outcome
Brief summary
To examine the effect of two different transfusion regimens on rehabilitation after hip fracture surgery.
Detailed description
The effect of liberal vs restrictive transfusion regimens after hip fracture surgery is unresolved. Liberal transfusion regimens (transfusion trigger hgb. 6.25 mmol/l) leads to an increased use of blood products but may impact positively on rehabilitation outcome, a restrictive transfusion trigger (hbg. 5.0 mmol/l) saves blood products but may also impair postoperative rehabilitation and outcome. the study randomizes 120 elderly patients with hip fractures to either a restrictive or a liberal perioperative transfusion therapy and measures postoperative rehabilitation outcomes within a well defined multimodal rehabilitation regimen.
Interventions
DRUGRed blood cell transfusion
Sponsors
IMK Fonden
Hvidovre University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Primary hip fracture * capable of informed consent * independently dwelling * able to ambulate independent of human assistance * no active heart condition defined as no AMI within 3 months, no unstable angina or present incompensation/pulmonary oedema * no regular transfusion demand or terminal disease.
Exclusion criteria
* Multiple fractures * postop. immobilization due to to surgical reasons * patient refusal to participate in relevant rehabilitation * reoperation within 4. postoperative day.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Functional mobility | — |
| Restricting factors for functional mobility | — |
Secondary
| Measure | Time frame |
|---|---|
| Dizziness | — |
| Length of stay | — |
| Haematoma (leg swelling) | — |
| Exhaustion | — |
| Complications | — |
Countries
Denmark
Outcome results
None listed