Pain
Conditions
Keywords
Bispectral index, sedation, remifentanyl, Bronchoalveolar lavage, Intensive care, Nociceptive stimuli, Sedated patient, BIS variation
Brief summary
The aim of this protocol is to study the prophylactic effect of remifentanil on bispectral index variation during a nociceptive stimuli.
Detailed description
Pain is difficult to estimate in ICU because most of the patients are sedated. Bispectral index could be helpful in detecting this pain in ICU patients. Remifentanil is a morphinomimetic product with short half life that could be interesting for short nociceptive stimuli, as bronchoalveolar lavage. The purpose of this study is to evaluate the impact of remifentanil infusion on bispectral index (BIS) variations during bronchoalveolar lavage. It is a prospective, double blind study, versus placebo on 40 sedated and critically ill patients. The hypothesis is that BIS can study analgesia in sedated patient.
Interventions
DRUGremifentanyl
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Sedated patient with mechanical ventilation with suspected nosocomial pneumonia
Exclusion criteria
* Pace maker * Neurologic illness * Hemodynamic instability * Hypothermia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BIS variation during bronchoalveolar lavage | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic blood pressure, diastolic blood pressure, heart rate viation | — |
Countries
France
Contacts
Primary ContactQUINTARD h Hervé, MD
Outcome results
None listed