Asthma
Conditions
Keywords
Albuterol, β2 Adrenergic receptor, Polymorphism
Brief summary
The response to salbutamol varies greatly among individuals. Data from previous studies indicate that some of the variability is accounted for by genetic polymorphisms in the gene encoding for the adrenoceptor subtype β2. The current study was designed to evaluate variability in the response to salbutamol among recently diagnosed patients who have not been treated by β2 agonists or corticosteroids. Lung function tests will be performed prior to and following a single dose administration of salbutamol through inhalation. Additional pharmacodynamic indices will be monitored including pulse and blood pressure. Three samples of plasma will be drawn for the evaluation of salbutamol plasma concentration.
Interventions
DRUGAlbuterol
Sponsors
Hadassah Medical Organization
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 18 years and older * Recently diagnosed as asthmatic
Exclusion criteria
* Current treatment by β2 agonist * Current treatment by corticosteroids * Acute asthma attack
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in lung function tests after salbutamol inhalation | — |
| Change in blood pressure and pulse after salbutamol inhalation | — |
Countries
Israel
Contacts
Primary ContactYoseph Caraco, MD
Outcome results
None listed