Metabolic Capacity of Israeli Populations

Phenotypic and Genotypic Evaluation of Cytochrome P450 Isoforms in Populations of Different Ethnic Composition

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00162383

Enrollment

1200

Registered

2005-09-13

Start date

1995-07-31

Completion date

2020-12-31

Last updated

2018-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteers

Brief summary

The ability to metabolize drugs varies greatly among individuals. Major fraction of this variability lies in genetic polymorphisms of genes encoding for enzymes responsible for both phase I and phase II reactions. The purpose of this study ws to evaluate the phenotypic activity and the frequency of genetic polymorphisms in different phase II and phase I enzymes among various populations residing in Israel.

Interventions

DRUGDebrisoquine

DRUGMephenytoin

DRUGDapsone

DRUGCaffeine

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Age range 20-50 * Absence of significant disease state

Exclusion criteria

* The presence of significant disease states * The regular use of drugs (including birth control pills)

Design outcomes

Primary

Measure	Time frame
Phenotypic measurements of various P450 and non-P450 enzymes involved in drug metabolism.	24 hours
Frequency of genetic polymorphisms in these enzymes among different Israeli populations.	24 hours

Countries

Israel

Contacts

Primary ContactYoseph Caraco, MD

caraco@hadassah.org.il00 972 2 6778584

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026