Chronic Obstructive Pulmonary Disease
Conditions
Keywords
Neuromuscular electrical stimulation
Brief summary
We intend to use repetitive magnetic stimulation to the quadriceps muscle to try to improve strength and improve the metabolic function of the muscle.
Detailed description
Quadriceps strength is reduced in COPD. Increasing quadriceps strength is one of the goals of pulmonary rehabilitation yet some patients with severe COPD are unable to exercise with sufficient intensity, due to breathlessness, to achieve a true training benefit. Transcutaneous electrical stimulation of the femoral nerve has been shown to improve quadriceps muscle strength, muscle mass, and performance in patients with severe COPD. Magnetic stimulation may be preferred because it offers the opportunity to train the whole muscle and because it is painless. In this pilot study we are investigating whether repetitive magnetic stimulation camn increase the strength of the quadriceps muscle and whether it confers any change in structure or metabolism of the muscle itself.
Interventions
DEVICERepetitive magnetic stimulation to the quadriceps
Sponsors
Magstim Company, Whitland, Wales
Imperial College London
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
Chronic Obstructive Pulmonary Disease
Exclusion criteria
Aspirin therapy Cardiac Pacemaker \-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quadriceps Twitch force | — |
Secondary
| Measure | Time frame |
|---|---|
| Quadriceps maximal voluntary contraction, Oxidative enzyme profile, fibre type distribution and capillarity of the muscle, quality of life questionnaires | — |
Countries
United Kingdom
Outcome results
None listed