Sedation
Conditions
Keywords
ICU mechanical ventilation analgesia sedation
Brief summary
The study will evaluate the pharmaco-economic consequences of the use of a remifentanil based regimen compared with a conventional sedative based regimen in terms of duration of mechanical ventilation, length of stay in ICU, difference in extubation time and use of concomitant sedative agents.
Interventions
DRUGmidazolam
DRUGlorazepam
DRUGfentanyl
DRUGmorphine
DRUGremifentanil
DRUGpropofol
Sponsors
GlaxoSmithKline
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ICU patients with an expected duration of mechanical ventilation for 2 to 3 days and requiring analgesia and sedation.
Exclusion criteria
* ICU patients resuscitated in the previous 24 hours, neurotrauma or expecting major surgery, not likely to survive of with limit care status.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Health Outcome: Duration of time on mechanical ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| Health Outcome: length of stay in ICU, in hospital, requirement of opioid and sedative agents, duration of extubation process. Safety: haemodynamics and adverse events. Efficacy: sedation and pain scores | — |
Countries
Netherlands
Outcome results
None listed