Deep Vein Thrombosis
Conditions
Keywords
deep vein thrombosis, DVT
Brief summary
To determine whether treatment and further investigation can be safely withheld in patients who present with suspected recurrent deep vein thrombosis (DVT) and have either a (i) negative D-Dimer or (ii) a positive D-Dimer with normal serial compression ultrasound.
Interventions
PROCEDUREvarious diagnostic measures for DVT (e.g., CUS)
Sponsors
Canadian Institutes of Health Research (CIHR)
McMaster University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 18 or older * Currently suspected for recurrent DVT * Has a prior history of objectively documented DVT or PE
Exclusion criteria
* Comorbid condition limiting survival to less than 3 months * History of hypersensitivity to contrast medium * Renal dysfunction with a creatinine of \> 150 mcmol/L * Treatment with full-dose therapeutic unfractionated or low molecular weight heparin that was initiated 24 hours or more prior to eligibility assessment * Pregnancy or lactation * Symptomatic for pulmonary embolism * Absence of symptoms within five days prior to presentation * Participation in another trial precluding the use of the diagnostic algorithm in this study * Geographically inaccessible for follow-up * Compression ultrasound, venogram, IPG, or D-dimer performed PRIOR to assessment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Suspected DVT during follow-up | — |
| Suspected PE during follow-up | — |
Countries
Canada, Netherlands
Outcome results
None listed