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Effects of Vitamin D Supplementation on Antimycobacterial Immunity

Effects of Vitamin D Supplementation on Antimycobacterial Immunity: A Randomised Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00157066
Enrollment
230
Registered
2005-09-12
Start date
2002-12-31
Completion date
2006-09-30
Last updated
2007-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tuberculosis

Keywords

Latent tuberculosis infection, Active tuberculosis infection

Brief summary

The purpose of this study is to determine how vitamin D supplementation (ergocalciferol) affects the immune response to mycobacterial infection.

Interventions

DRUGErgocalciferol

Sponsors

Imperial College London
CollaboratorOTHER
University of Cape Town
CollaboratorOTHER
Newham Chest Clinic, London E7 8QP, UK
CollaboratorUNKNOWN
Northwick Park Hospital, Harrow, UK
CollaboratorOTHER
Department of Clinical Biochemistry, Homerton Hospital, London E9 6SR, UK
CollaboratorOTHER
Environmental Health Department, London Borough of Newham, London E15 4SF, UK
CollaboratorUNKNOWN
Wellcome Trust
CollaboratorOTHER
Barts & The London NHS Trust
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
DOUBLE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum

Inclusion criteria

* Adult * Tuberculosis (TB) contact or TB patient

Exclusion criteria

* Pregnancy * Breastfeeding * Hyperparathyroidism * Sarcoidosis * Renal failure * HIV infection

Design outcomes

Primary

MeasureTime frame
Bacillus Calmette-Guerin (BCG) lux whole blood assay—

Secondary

MeasureTime frame
Antigen-stimulated whole blood interferon gamma production—

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026