Skeletal Muscle Dysfunction in Heart Failure

Training and Congestive Heart Failure

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00156234

Enrollment

Registered

2005-09-12

Start date

2005-03-31

Completion date

Unknown

Last updated

2005-09-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure, Congestive

Brief summary

Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart. We hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.

Interventions

BEHAVIORALOne-knee extension ergometer

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

ECT

Masking

SINGLE

Eligibility

Sex/Gender

ALL

Age

40 Years to 78 Years

Healthy volunteers

Yes

Inclusion criteria

* Coronary Heart Failure * Ejection fraction \<35% * NYHA 2-3 * Spirometry FEV1 \> 80%

Exclusion criteria

* Cardiomyopathy * Transplantation candidate * Active malignancy * Restraining skeletal-muscular disease * Claudication in legs * Hospitalized last 30 days due to acute ischemic episode * Intravenous inotrope or vasodilatating drugs last 14 days prior to inclusion * AMI last 8 weeks prior to inclusion * Organized training last 4 months * Smoking on daily basis last 4 months * Creatinin \< 150microliters/liter

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026