MR Scanning of Very Young Children With Severe Developmental Disorders

MR Scanning of Very Young Children With Severe Developmental Disorders (Autistic Spectrum Disorders and/or Mental Retardation and/or Language Disorders)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00156221

Enrollment

Unknown

Registered

2005-09-12

Start date

2000-09-30

Completion date

2005-09-30

Last updated

2005-09-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism, Language Disorder, Mental Retardation

Keywords

Autism, MRI, Developmental Disorders

Brief summary

The specific is to study the MR morphologic and spectroscopic brain correlates and predictors of development in children with severe developmental disorders (autistic spectrum disorders and/or mental retardation and/or language disorders). Given the frequently observed association of autism with known medical conditions, particularly in cases with comorbid mental retardation and in cases with atypical autism (Rutter et al., 1994; Gillberg, 1995), children with suspected autism or related developmental disorders will be asked to participate in an extensive state of the art laboratory work-up which includes T1 and T2 weighted MRI of the brain. MRI data will be analyzed both qualitatively, looking for focal abnormalities and degree of myelination, and quantitatively, measuring volumes of total brain, cerebellum, ventricles and grey and white matter. For research purposes, the work-up will be supplied with proton Magnetic Resonance Spectroscopy (MRS) of the brain. This data set provides the opportunity to chart brain-behavior relationships in young children with suspected autism and related PDD cross-sectionally.

Interventions

None listed

Study design

Observational model

NATURAL_HISTORY

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Months to 7 Years

Healthy volunteers

Inclusion criteria

* Age 18 months to 7 years * Diagnosis of autism spectrum disorder, a language disorder or mental retardation

Exclusion criteria

* Significant motor or sensory impairment * Major physical abnormalities * History of serious head injury * Identifiable neurologic disorder * Metal implants * Contraindication for MRI

Countries

Netherlands

Outcome results