Systemic Lupus Erythematosus
Conditions
Keywords
Peripheral neuropathy;systemic lupus erythematosus
Brief summary
To address the issues of skin denervation and its clinical and pathological correlations in systemic lupus erythematosus
Detailed description
To address the issues of skin denervation and its clinical and pathological correlations in lupus, we will study a systemic lupus erythematosus (SLE) cohort by evaluating the extent of cutaneous innervation. Patients are recruited from the rheumatologic clinic, and various neuropsychiatric syndromes are diagnosed based on clinical judgement following detailed history taking and neurological examinations. Skin biopsy with PGP 9.5 immunohistochemistry will be performed following established procedures after informed consent is obtained, and punches of 3 mm in diameter will be taken from the lateral side of the distal leg, 10 cm above the lateral malleolus. Intraepidermal nerve fibre densities will be compared with results of immunological, pathological, psychophysical, and electrophysical studies to understand the pathogenesis of peripheral neuropathy in SLE.
Interventions
PROCEDURE3 mm-punch biopsies of the skin
Sponsors
National Taiwan University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
* Diagnosis of systemic lupus erythematosus based on the consensus criteria
Exclusion criteria
* Conditions known to be associated with peripheral neuropathy, such as diabetes, uremia, alcoholism, and the administration of potentially neurotoxic agents, such as alkylating agents, methotrexate, cyclosporine, and antibiotics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitation of epidermal innervation | — |
Countries
Taiwan
Outcome results
None listed