Corneal Ulcer, Pterygium
Conditions
Keywords
fibrin glue, corneal perforation, pterygium, conjunctiva, corneal ulcer
Brief summary
This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries, which includes pterygium surgery, corneal melting/perforation, Gunderson's flap, conjunctival laceration, and muscle/clinical/filtering surgery.
Detailed description
This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries. The inclusion criteria are: 1. ocular surface disease which may need amniotic membrane transplantation (corneal pro epithelization, pterygium surgery, etc) 2. infectious or noninfectious corneal ulcer with perforation less than 3 mm 3. conjunctival transplantation/suture 4. corneal surgeries which can be treated by conventional suture technique or application with cyanoacrylic acid tissue glues. Informed consents will be obtained from the patients before applications. After surgeries, topical steroids and antibiotics will be used, and therapeutic contact lens will be used. The patients will be followed up for at least three months.
Interventions
DRUGtissue fibrin glue application (Tisseel)
Apply several droplets within several seconds to several minutes
Sponsors
National Taiwan University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Ocular surface diseases, which are expected to be treated by tissue fibrin glues
Exclusion criteria
* Pregnancy * Children younger than 3 years old
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cure of the diseases | 1week, 2 weeks, 3 weeks, 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| integrity of the ocular surface | 1week, 2 weeks, 3 weeks, 4 weeks |
| visual acuity | 1week, 2 weeks, 3 weeks, 4 weeks |
Countries
Taiwan
Outcome results
None listed