The Role of CGRPand Nociceptin in Migraine

The Role of Calcitonin Gene-Related Peptide(CGRP)and Nociceptin in the Pathogenesis of Migraine

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00155129

Enrollment

200

Registered

2005-09-12

Start date

2005-01-31

Completion date

2005-06-30

Last updated

2005-09-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Headache, Migraine

Keywords

migraine, CGRP, nociceptin

Brief summary

The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was co-localized with CGRP. It may play a role in migraine pathogenesis. We are collecting the blood samples of migraineurs for analysis of these neuropeptides.

Detailed description

Interventions

None listed

Study design

Observational model

DEFINED_POPULATION

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

3 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

patients with headache -

Exclusion criteria

fever, congenital anomaly, CNS organic lesions \-

Countries

Taiwan

Contacts

Primary ContactPi-Chuan Fan, MD

pcfan@ntumc.org

Backup ContactLi-Chu Chiou, PhD

Outcome results