Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00155103

Enrollment

1600

Registered

2005-09-12

Start date

2004-08-31

Completion date

Unknown

Last updated

2007-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carcinoma, Hepatocellular, Hepatitis B, Polymorphism, Genetic

Keywords

Hepatitis B, Carcinoma, Hepatocellular, Polymorphism, Genetic

Brief summary

The purpose of this study is to determine the effect of polymorphisms in the IL-1 gene complex on the development of chronic hepatitis and hepatocellular carcinoma.

Detailed description

We analyzed single-nucleotide polymorphisms in the genes for interleukin-1a, interleukin-1b, interleukin-1-receptor antagonist, interleukin-1-receptor type I, and interleukin-1-receptor type II in 400 normal control and patients (chronic hepatitis and hepatocellular carcinoma). Genotypes were tested for an association with development of chronic hepatitis and hepatocellular carcinoma by multivariable analysis. A second cohort of 1200 normal control and patients (chronic hepatitis and hepatocellular carcinoma) was independently analyzed for the genotype associations identified in the first cohort.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Normal controls * Cases of chronic hepatitis and hepatocellular carcinoma

Exclusion criteria

* Pregnant women

Countries

Taiwan

Contacts

Primary ContactLi-Hui Tseng, M.D., Ph.D.

htseng@ha.mc.ntu.edu.tw+886-2-2312-3456

Backup ContactFang-Yu Chan, B.A.

p93448006@ntu.edu.tw+886-2-2312-3456

Outcome results