Cardiovascular Disease, Cerebrovascular Disorders
Conditions
Brief summary
The aim of the study is to investigate whether intravenous infusion of pantoprazole (Pantoloc) is effective in preventing recurrent bleeding in patients who present with acute ulcer bleeding and continue to use aspirin
Detailed description
Aspirin is an effective treatment for acute stroke and heart attack. However, aspirin also induces ulcer and provokes acute ulcer bleeding. Thus, aspirin is often withheld in acute ulcer bleeding but this precipitate recurrent stroke or heart attack. We previously showed that intravenous infusion of a potent acid suppressant substantially reduced the incidence of recurrent ulcer bleeding in patients who withheld aspirin. The aim of this study is to investigate whether intravenous infusion of an acid suppressant (Pantoprazole) is effective in preventing recurrent ulcer bleeding with continuous use of aspirin.
Interventions
DRUGAspirin and Pantoloc
Sponsors
Chinese University of Hong Kong
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients received daily anti-platelet therapy for vascular prophylaxis before admission and will continue need to do so * Patinets with bleeding peptic ulcers;ulcer actively bleeding or with SRH (Forrest I, IIa and IIb ulcers) * Endoscopic haemostasis achieved
Exclusion criteria
* Presence of ulcer complication precluding endoscopic treatment such as gastric outlet obstruction or ulcer perforation mandating surgical intervention. * Concomitant use of anticoagulant, NSAIDs or steroid * Pending to undergo cardiac interventions that need double anti-platelet agent * Pregnancy * Terminal illness, or cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome: | — |
| Recurrent upper gastrointestinal bleeding within 30 days | — |
Countries
China
Outcome results
None listed