Prostatic Neoplasms
Conditions
Brief summary
This study is based on previous observation that, in men with localized prostate cancer, non-cancerous prostate tissue is hypoxic, and on the known contribution of hypoxia to the progression of cancer. Patients undergoing diagnostic prostate biopsy with serum prostate specific antigen (PSA) less than 10ng/ml and who have given informed consent will have oxygen measurements of the prostate and peri-prostatic tissue taken with the Eppendorf electrode at the time of biopsy. The oxygenation of normal prostate tissue will be compared to that of cancerous prostate tissue. In men with negative biopsies, the prostate tissue oxygen measurements will be compared with the peri-prostatic tissue oxygen measurements.
Interventions
PROCEDUREOxygen measurement - Eppendorf machine
Sponsors
Princess Margaret Hospital, Canada
University Health Network, Toronto
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Men due to undergo sextant prostate biopsy * Serum PSA \<10 ng/ml
Exclusion criteria
* Previous diagnosis of prostate cancer * Inability to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Median pO2 and HP5 will be analyzed according to the presence or absence of tumour on biopsy | 7 years |
Secondary
| Measure | Time frame |
|---|---|
| Median pO2 and HP5 for the prostate gland in each patient with negative biopsy result will be compared with the median pO2 and HP5 for peri-prostatic tissue. | 7 years |
Countries
Canada
Outcome results
None listed