Healthy Volunteers
Conditions
Keywords
Physiology, Microcirculation, Laser-Doppler Flowmetry
Brief summary
Microvascular dysfunctions are critical events in several diseases including diabetes. This study will develop a methodology for microvascular investigation in human skin. The purpose of the study is to investigate the physiological response of the cutaneous microcirculation to physical, thermal, mechanical or chemical stimulations.
Detailed description
This study has investigated various aspects of the physiology of the microcirculation in the past years and is still recruiting under parallel protocols of physiological investigations of the neurovascular control of the cutaneous microcirculation.
Interventions
DEVICEpressure strain system, iontophoresis
DRUGscopolamin
DRUGemla
DRUGcapsaicin
DRUGaspirin
DRUGclopidogrel
DRUGcelecoxib
DRUGindomethacin
DRUGacetylcholine
DRUGsodium nitroprusside
DRUGbrethyllium
DEVICEgeneral and local heating
Sponsors
University Hospital, Angers
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers with no clinical signs of, or risk factors for, vascular disease
Exclusion criteria
* Smokers, Pregnancy, Allergy,
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amplitude of the vasomotor response to stimuli | 1 hour |
Secondary
| Measure | Time frame |
|---|---|
| Kinetics of the vasomotor response to stimuli | 1 hour |
Countries
France
Outcome results
None listed