Peripheral Arterial Disease
Conditions
Brief summary
The aim of the study is to show the implication of platelets in vasodilation using in vivo and in vitro analysis and to compare the effects of placebo, aspirin and Clopidogrel in this interaction platelets/vessels. The effects of 7 days of each treatment will be compared in healthy subjects and patients with arteriopathy.
Interventions
DRUGplacebo, aspirine, clopidogrel
Sponsors
University Hospital, Angers
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria healthy subjects * Man or Woman 18 years * Agreement signed * French health insurance * Able to understand the study * Biological haemostatic test normal * Vascular Doppler of lower limbs normal * Pressure index \> 1 in both lower limbs Inclusion criteria healthy subjects * Man or Woman 18 years * Agreement signed * French health insurance * Able to understand the study * Biological haemostatic test normal * Lower limbs arteriopathy (clinical, pressure index, Doppler)
Exclusion criteria
* Unable to sign agreement * Subjects protected by low * Participation to other study * Changes of treatment within the 15 days before inclusion * Chronic treatment with Clopidogrel or drugs against inflammation * Severe respiratory, cardiac, kidney, hepatic insufficiency * Haemostatic troubles * Diabetic neuropathy * Neurologic desease (Parkinson…..) * Hypertension * Symptomatic stomach ulcer * Anaemia Hb\<11g/l * Pregnant women or breast feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In vivo vasodilation induced by low intensity current | — |
| In vitro study of platelets function | — |
| In vitro vasodilation induced by platelets in isolated rat's vessels | — |
Countries
France
Outcome results
None listed