Hypertension
Conditions
Keywords
endothelium, hypertension, retina, AT1
Brief summary
Essential hypertension is commonly associated with impaired endothelial function. The retinal vasculature is morphologically and functionally related to the cerebral vessels because of the common origin from the internal carotid artery. A recent study in hypertensive patients demonstrated that endothelial function of the retinal vasculature is impaired in hypertensive patients and that it can be restored by treatment with an AT1-receptor antagonist. It is not clear whether this effect is due to blood pressure lowering or whether this is a blood pressure independent effect. The present randomized, double blind study with a cross over design addresses this issue by comparing the effects of losartan and metoprolol on retinal endothelial function in patients with essential hypertension.
Interventions
DRUGLosartan
DRUGMetoprolol
Sponsors
Merck Sharp & Dohme LLC
University of Erlangen-Nürnberg Medical School
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Male and female patients aged 18-65 years with essential hypertension
Exclusion criteria
* Secondary forms of hypertension * Advanced damage of vital organs (grade III and IV retinopathy) * History of serious hypersensitivity reaction to AT1-receptor blockers * Actual or anamnestic alcohol- or drug abuse. * Smokers or ex-smokers \< 1 year. * Patients with Diabetes mellitus (oral medication or insulin). * Patients with arterial fibrillation or AV-Block (II° or more). * Patients with anamnestic myocardial infarction. * Patients with instable angina pectoris including EcG-aberrations or cardiac insufficiency NYHA III or IV. * History of malignancy (unless a documented disease-free period exceeding 10 years is present) with teh exception of basal cell carcinoma of the skin * History of allograft transplantation * Therapy with not approved concomitant medication, or participation in a clinical study within 4 weeks preceding treatment start. * Disease which interfere with the pharmacodynamics and pharmacokinetics of the study drug. * Liver-or kidney disease with SGOT, GPT, g-GT, AP, bilirubin and creatinin or above 200% of standard. * Patients, who are not sufficiently compliant, or patients, who are not capable or willing to appear for controlling vistas. * Presumed risk of transmission of HIV or hepatitis via blood from the participant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in retinal endothelial function | — |
Countries
Germany
Outcome results
None listed