Congenital Adrenal Hyperplasia
Conditions
Brief summary
Congenital adrenal hyperplasia, an autosomal recessive condition, is mainly caused by mutations in the gene 21-hydroxylase and is treated with glucocorticoids in a slightly supraphysiological dose. Adult patients seem to be characterized by insulin resistance, which may be caused by the glucocorticoids and/or the accompanying obesity. The hypothesis of this study is that pioglitazone can improve insulin sensitivity and correlated cardiovascular risk factors in this specific group of patients. This will be tested in a randomized, placebo-controlled, cross-over trial; insulin sensitivity will be quantified by euglycemic hyperinsulinemic clamp studies.
Interventions
DRUGPioglitazone
Sponsors
Radboud University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* biochemical and genetically proven congenital adrenal hyperplasia * stable corticosteroid replacement for 3 months
Exclusion criteria
* age \< 18 years * inability to give informed consent * significant cardiovascular disease, defined as myocardial infarction or stroke, six months preceding the study * significant renal disease, GFR \< 30 ml/min * significant liver disease, defined as more than 3 times upper limit of normal values of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) * pregnancy * mental disease
Countries
Netherlands
Outcome results
None listed