Burns
Conditions
Keywords
Burn, adrenal insufficiency, hydrocortisone, short corticotropin test
Brief summary
Major burns trigger the release of circulating mediators, as cytokines and endotoxin that induces a systemic inflammatory response syndrome. The cardiovascular effects are similar to those seen in septic shock. After the initial hypovolemic phase, patients with extensive burns often present a shock with increased cardiac output and reduced systemic vascular resistances. As described in septic shock, we test the hypothesis that low-dose hydrocortisone could decrease the duration of the shock period.
Interventions
DRUGhydrocortisone 200 mg/day
Sponsors
Hospices Civils de Lyon
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* males and females, * between 18 and 75 year old * who present a burned surface more than 30% of the body surface * who need catecholamine infusion * between J0 and J3 after the injury.
Exclusion criteria
* pregnancy, * trauma, * sepsis, * cardiac insufficiency, * AIDS, * etomidate administration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients who do not receive any more catecholamine 4 days after the beginning of the shock | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of catecholamine administration | — |
| Doses of administered catecholamine | — |
| Adrenal insufficiency incidence | — |
Countries
France
Outcome results
None listed