Changes in Nasal Patency With Changes in Posture, Temperature, Humidity and Nasal Patency Seen by Acoustic Rhinometry

Physiological Changes in Nasal Patency in Response to Changes in Posture, Temperature, Humidity and Nasal Patency Measured by Acoustic Rhinometry

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00147888

Enrollment

Registered

2005-09-07

Start date

2004-03-31

Completion date

2006-12-31

Last updated

2013-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mucosal Congestion

Keywords

Mucosal congestion, Acoustic rhinometry, Physiology

Brief summary

To study nasal physiologic responses to changes in posture, temperatures, humidity and nasal patency with acoustic rhinometry.

Detailed description

The purpose of this study was to utilize acoustic rhinometry to assess changes in nasal patency after alterations in posture, unilateral mechanical obstruction, temperature, and humidity. Eight healthy adult volunteer subjects underwent acoustic rhinometry under the following conditions: 1) upright, sitting position (control), 2) supine position, 3) left lateral recumbent position, 4) one nostril mechanically blocked, 5) icepack on neck, 6) drinking cold water, 7) drinking hot water, 8) nasal nebulizer, 9)oxymetazoline decongestant. Changes in nasal cavity volumes were detected by acoustic rhinometry after alterations in posture, unilateral mechanical obstruction, temperature, and humidity. Nebulizer treatment and hot water ingestion caused a significant decrease in nasal volume. The nose was able to adapt to environmental and physiological changes in order to maintain a consistent total nasal volume.

Interventions

PROCEDUREAcoustic rhinometry (procedure)

Acoustic rhinometry is a procedure that uses sound waves to measure the cross-sectional area and volume of the nasal cavity.

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 58 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteers, 18-58 years old

Exclusion criteria

* Any nasal symptoms in the last 3 weeks * Marked septal deviation/polyposis/infection * Any history of allergy, asthma or immunodeficiency * Any systemic condition or infection (e.g., hypertension/diabetes/heart, liver, thyroid or kidney disease * Any spine or neck condition that would not allow normal postures * Pregnancy

Design outcomes

Primary

Measure	Time frame
Changes in nasal patency	5-10 minutes

Secondary

Measure	Time frame
Nasal volume	5-10 minutes

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026