Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00146926

Enrollment

200

Registered

2005-09-07

Start date

2005-09-30

Completion date

Unknown

Last updated

2007-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induction of Total Intravenous General Anesthesia

Keywords

Propofol, pain, general anesthesia, prevention

Brief summary

Propofol is a popular intravenous drug to induce anesthesia but it causes local pain with an incidence between 40 and 90%. Three different strategies to prevent propofol induced pain will be studied compared with placebo. Pain will be scored with a four-point scale.

Interventions

DRUGkétamine 20mg

DRUGephedrine 3mg

DRUGlidocaine 40mg

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

Healthy adults (ASA 1-2) for scheduled surgery under general anesthesia with propofol

Exclusion criteria

* pregnant * sedative or analgesic drug 24h before surgery * allergy with drug used in the study * difficulty of communication * absence of informed written consent

Design outcomes

Primary

Measure	Time frame
After prophylactic solution, evaluation of the pain caused by injection of propofol with a four-point scale before lose of consciousness	—

Secondary

Measure	Time frame
Explicite and implicite memory of pain immediately after surgery and on day one	—
Adverse effects	—

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026