Elderly, Frailty, Obesity
Conditions
Keywords
Obesity, Aging, Frailty, exercise, weight loss
Brief summary
The overall purpose of this research is to determine the effect of weight loss and physical training on quality of life, physical function, metabolism, bone strength, body fat and muscle mass.
Detailed description
Obesity causes serious medical complications and impairs quality of life. Moreover, in elderly persons, obesity can lead to frailty because of decreased strength, joint function, balance and mobility associated with aging. The primary objective of this study is to evaluate the effect of weight loss and physical training on physical function, body composition, metabolism and quality of life in frail, obese elderly men and women. Subjects are randomized to either control or 10% weight loss plus physical training.
Interventions
BEHAVIORALdiet, exercise
Sponsors
Washington University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
65 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Obese (BMI 30 or greater) elderly (age 65 years or older) Frailty
Exclusion criteria
* Major chronic disease or any condition that would interfere with exercise or dietary restriction, in which exercise or dietary restriction are contraindicated, or that would interfere with interpretation of results. Examples include cardiopulmonary disease, unstable disease, severe orthopedic or neuromuscular impairments, dementia, history of malignancy during the past 5 yr, current use of bone acting drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| physical function and body composition | — |
Secondary
| Measure | Time frame |
|---|---|
| quality of life, metabolic markers | — |
Countries
United States
Outcome results
None listed