Obesity
Conditions
Keywords
obesity, aging, exercise, diet, weight loss, physical function, Obesity in the Elderly
Brief summary
The purpose of this study is to determine the effect of weight loss and exercise on physical function, body fat and muscle mass, bone strength, and quality of life.
Detailed description
Obesity causes serious medical complications and impairs quality of life. Moreover, in elderly persons, obesity can lead to frailty by exacerbating the decline in strength, endurance, balance and mobility associated with aging and physical inactivity. The primary objectives of the proposed research are to evaluate the independent and combined effects of weight loss and exercise on physical function, body composition, bone and muscle metabolism, and quality of life in frail, obese elderly men and women. The central hypothesis is that in frail obese elderly subjects, weight loss will improve physical function and quality of life, while the addition of exercise will not only augment improvement in these outcomes, but also attenuate the adverse effects of weight loss on bone and muscle masses. To test this hypothesis, 110 elderly (65-85 years old) obese men and women (body mass index \[BMI\] \> 30 kg/m2) with physical frailty will be randomized to 4 treatment groups: 1) control, 2) 10% weight loss, 3) exercise training, and 4) 10% weight loss plus exercise training.
Interventions
BEHAVIORALDiet
10 percent weight loss through diet and behavioral modification
OTHERExercise
Multicomponent (resistance, aerobic, balance) exercise three times a week
10% weight loss through diet and exercise plus multicomponent exercise training three times a week
Sponsors
Washington University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Obese (BMI 30 or greater) * Elderly (age 65 years or older) * Frailty
Exclusion criteria
* Major chronic disease or any condition that would interfere with exercise or dietary restriction, in which exercise or dietary restriction are contraindicated, or that would interfere with interpretation of results. * Examples include cardiopulmonary disease, unstable disease, severe orthopedic or neuromuscular impairments, dementia, history of malignancy during the past 5 years, or current use of bone acting drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| physical function | one year |
Secondary
| Measure | Time frame |
|---|---|
| muscle protein synthesis | one year |
| quality of life | one year |
| body composition | one year |
| metabolism | one year |
| bone mineral density | 1 year |
| cognition and mood | one year |
Countries
United States
Outcome results
None listed