Osteopenia, Osteoporosis
Conditions
Keywords
Osteopenia, osteoporosis, bone mineral density, HIV infection, bone metabolism, Treatment Naive
Brief summary
Osteopenia and osteoporosis are increasingly reported in HIV-infected patients, and appear to be more frequent than in general population. However, pathogenesis remains unclear, and published studies still give non concordant results. We therefore started a prospective study, to assess the potential role of ARV in the occurrence of osteopenia and osteoporosis. BMD evolution over a 2-years period of follow-up, will be compared between patients starting ARV therapy, and subjects without HAART (no indication of treatment). A correlation between BMD and several factors will be looked at (see below). This study with individual direct benefice, is conducted in 3 outpatients clinics (Strasbourg, Colmar, Mulhouse) in collaboration with the rheumatologic teams. 60 patients are planned to be included over a 3-years inclusion period
Interventions
DRUGantiretrovirals
Treated with antiretrovirals
PROCEDUREBMD Measurement
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* HIV-1 infected men, Caucasian, age \> 18 years, ARV-naïve
Exclusion criteria
* HIV-infected women, subjects \< 18 years, non-Caucasian men, ARV-experienced patients, subjects not able or willing to give informed consent, endocrine disease or treatment which could affect bone metabolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BMD evolution and modification during 2 years of follow-up, compared between treated and untreated subjects | From enrollment to the end of follow-up at 2 years |
Countries
France
Outcome results
None listed