Arteriosclerosis Obliterans, Buerger Disease
Conditions
Keywords
critical limb ischemia, bone marrow mononuclear cells, angiogenesis, vasculogenesis, Arteriosclerosis Obliterans (ASO), Ischemic ulcers
Brief summary
Clinical studies have established that implantation of bone marrow mononuclear cells (BM-MNCs) or peripheral blood mononuclear cells (PB-MNCs) into ischaemic limbs increases collateral vessel formation. We, the investigators at Nagoya University, further investigated the efficacy and safety of autologous implantation of BM-MNCs or PB-MNCs in patients with severe ischaemic limbs who have no other alternative therapeutic options. We also examined a potential limiting factor which reduced the efficacy of therapeutic angiogenesis using cell transplantation (TACT).
Interventions
PROCEDUREAutologous Bone Marrow Mononuclear Cell Implantation
Sponsors
Nagoya University
Study design
Observational model
DEFINED_POPULATION
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Subjects who have chronic limb ischemia, including rest pain, non-healing ischemic ulcers, or both, and who are not candidates for nonsurgical or surgical revascularisation.
Exclusion criteria
* Poorly controlled diabetes mellitus (hemoglobin A1c \[HbA1c\] \> 6.5% and proliferative retinopathy) * Evidence of malignant disorder during the past 5 years * Subjects who cannot survive more than 1 year with other complications * Malignant rheumatic arthritis
Countries
Japan
Contacts
Primary ContactMurohara Toyoaki
Outcome results
None listed