Natural History Study of Azathioprine Adherence

Measurement of Compliance in Renal Transplant Recipients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00143910

Enrollment

180

Registered

2005-09-02

Start date

1993-04-30

Completion date

1999-10-31

Last updated

2023-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Transplant

Keywords

Medication adherence, Patient compliance, Kidney transplant, Organ rejection, Allograft loss, Drug monitoring

Brief summary

This study began in 1993 as a prospective, natural history study of renal transplant patients' medication compliance measured by using an electronic monitor on the cap of medication vials. Hypothesis: Poor medication compliance predicts adverse outcomes. Enrollment is closed.

Detailed description

* The study is complete. Patient recruitment is closed and active patient involvement in the study has ended. * Statistical analysis of monitor records and new patient outcome data continues

Interventions

OTHERobservation

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Inclusion criteria

* Kidney transplant recipient * Discharged from hospital with functioning graft,not on dialysis * Prescribed azathioprine

Exclusion criteria

* Unable to give informed consent * Non English speaking * Previous or concurrent organ transplant other than kidney * Taking liquid form of azathioprine * Followed outside of the United states

Design outcomes

Primary

Measure	Time frame
acute transplant rejection	10 years

Secondary

Measure	Time frame
Allograft loss	10 years

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026