Amlodipine vs Nitrates Study in Patients With Chronic Stable Angina

Open Label Study Comparing Amlodipine vs Long-acting Nitrates in Patients With Chronic Stable Angina.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00143195

Acronym

ANISSA

Enrollment

200

Registered

2005-09-02

Start date

2001-04-30

Completion date

2005-01-31

Last updated

2021-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Ischemia

Brief summary

The objective of study is to compare the anti-ischemic efficacy and safety profiles of once daily amlodipine or isosorbide-5-mononitrate in the treatment of stable asymptomatic and symptomatic myocardial ischemia

Interventions

DRUGAmlodipine

DRUGiso- 5 - mononitrate

PROCEDUREBlood tests

PROCEDUREExercise Stress Test

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Outpatients \> =18 years of age with diagnosed clinically stable angina pectoris

Exclusion criteria

* Patients with congestive heart failure, clinically significant cardiovascular disease, standing systolic blood pressure of less than 100mmHg, concomitant anti-anginal therapies similar to sublingual NTG

Design outcomes

Primary

Measure	Time frame
Evaluate the time to 1mm ST depression	—

Secondary

Measure	Time frame
The number of patients experiencing angina attacks The frequency of hospitalizations due to angina attacks Time to onset of 1mm ST segment depression Total external workload performed Safety	—

Countries

Greece

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026