Losartan and HCTZ and Amlodipine vs Atenolol and Amlodipine (0954A-309)(COMPLETED)

Antihypertensive Effects of a Fixed-dose Combination of Losartan and Hydrochlorothiazide Plus Amlodipine Versus a Hydrochlorothiazide and Atenolol Combination Plus Amlodipine in Subjects With Ambulatory Systolic Hypertension.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00140959

Enrollment

120

Registered

2005-09-01

Start date

2003-02-01

Completion date

2004-06-30

Last updated

2024-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Brief summary

A study to evaluate the effects of combination losartan versus combination atenolol in patients with ambulatory systolic hypertension.

Interventions

DRUGMK0954, losartan potassium/Duration of Treatment: 18 weeks

DRUGComparator: losartan, HCTZ, amlodipine, atenolol/Duration of Treatment: 18 weeks

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Males or females at least 18 years of age who have ambulatory systolic hypertension.

Design outcomes

Primary

Measure	Time frame
Mean daytime ambulatory systolic blood pressure	—

Secondary

Measure	Time frame
Ambulatory BP	—
Pulse pressure	—
Trough sitting BP	—
Percentage of patients who reach goal ambulatory systolic BP	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026