Ambulatory Blood Pressure Monitoring for Antihypertensive Treatment Guidance

Impact of Ambulatory Blood Pressure Monitoring for Antihypertensive Treatment Guidance in Medical Outpatients: The Hyper-ABC Study

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00139984

Enrollment

170

Registered

2005-08-31

Start date

2003-10-31

Completion date

2007-05-31

Last updated

2017-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Keywords

Hypertension, Ambulatory blood pressure monitoring, Blood pressure, Risk assessment

Brief summary

The purpose of this study is to determine whether in patients with arterial hypertension, treatment guidance using 24-hour blood pressure measurement results in better blood pressure control compared to treatment guidance using office blood pressure measurement.

Detailed description

Blood pressure control in arterial hypertension remains poor, despite the availability of effective drug treatment. Therefore, strategies to increase blood pressure control are urgently needed. 24 hour blood pressure is a better predictor of cardiovascular morbidity and mortality than office blood pressure. Furthermore, the lower variability of measurements over time of 24 hour blood pressure could allow better adjustment of antihypertensive therapy. However, there are only scarce data about antihypertensive treatment adjustment using 24 hour blood pressure instead of office blood pressure. Aim: To test the hypothesis that a 24 hour blood pressure guided therapy is is more effective in reaching blood pressure control when compared to conventional office blood pressure guided therapy.

Interventions

DEVICE24 hour blood pressure measurement

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Uncontrolled hypertension (office BP \>139/89mmHg AND 24h BP \>129/79mmHg)

Exclusion criteria

* Severe concomitant illness including heart failure, significant valvular heart disease or malignancy

Design outcomes

Primary

Measure	Time frame
Change in 24-hour systolic blood pressure from baseline to 1 year	—

Secondary

Measure	Time frame
Change in 24-hour diastolic blood pressure from baseline to 1 year	—
Primary outcome measure in patients with treated hypertension at baseline	—

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026