Ghrelin, Growth Hormone and Cortisol Interaction in Growth Hormone Deficient Patients

Effects of Acute Ghrelin Infusion to Growth Hormone Deficient Adults: Growth Hormone and Cortisol Interaction

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00139945

Enrollment

Registered

2005-08-31

Start date

2005-10-31

Completion date

2007-03-31

Last updated

2010-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypopituitarism

Brief summary

In growth hormone deficient patients: Determination of endogenous circulating ghrelin levels, ghrelin effects on insulin sensitivity, appetite, energy metabolism, and signal transduction in fat and muscle.

Interventions

DRUGHuman acylated ghrelin

5 pmol/kg body weight per min

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Age between 18 and 60 yrs. * Verified hypopituitarism * Unchanged substitution treatment through 3+ months * Unchanged additional medical treatment * Oral and written informed consent

Exclusion criteria

* Age below 18 or above 60 yrs. * Diabetes mellitus * body mass index \> 30 * Fasting hypoglycemia * Convulsions * Allergy to trial products

Design outcomes

Primary

Measure	Time frame
Endogenous serum ghrelin levels	Same day as intervention

Secondary

Measure	Time frame
Insulin sensitivity, appetite, metabolism, intracellular signal transduction	Same day as intervention

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026