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High Frequency Stimulation of the GPi or Thalamus in Tourette's Syndrome

Pilot Study of Internal Globus Pallidus or Median Centre of the Thalamus High Frequency Stimulation for the Treatment of Patients With Severe Tourette's Syndrome

Status
Completed
Phases
Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00139308
Enrollment
Unknown
Registered
2005-08-31
Start date
Unknown
Completion date
Unknown
Last updated
2005-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tourette's Syndrome

Keywords

Tourette's syndrome, High frequency stimulation, Globus pallidus, Thalamus

Brief summary

Tourette's syndrome is a disabling neuropsychiatric disorder with major psychosocial consequences in some patients. The pathophysiology is still unknown. Some data suggest an dysfunction of limbic circuits in basal ganglia. The aim of this study is to evaluate the effect of high frequency stimulation of the internal part of the globus pallidus and/or parafascicular-median centre of the thalamus, two structures implicated in the limbic circuit, in patients with severe Tourette's syndrome.

Interventions

DEVICEhigh frequency stimulation

Sponsors

Institut National de la Santé Et de la Recherche Médicale, France
CollaboratorOTHER_GOV
Groupe Hospitalier Pitie-Salpetriere
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE

Eligibility

Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No

Inclusion criteria

* Tourette's syndrome (DSM IV) * inducing a disability in the social and personal life * No improvement with medical treatment * Severe self suffering

Exclusion criteria

* Cognitive impairment (MMS \< 24) * Depression

Design outcomes

Primary

MeasureTime frame
Severity of tics—

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026