Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis

Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis. A Randomized Double-blind Comparison

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00138801

Enrollment

120

Registered

2005-08-30

Start date

2004-03-31

Completion date

2008-12-31

Last updated

2023-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lyme Neuroborreliosis

Keywords

Neuroborreliosis

Brief summary

The aim of this study is to compare parenteral ceftriaxone and oral doxycycline in the treatment of neuroborreliosis in a randomized controlled trial.

Interventions

DRUGCeftriaxone

DRUGDoxycycline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* Neurological symptoms and/or findings consistent with neuroborreliosis and at least one of the following fulfilled: * Intrathecal production of borrelia antibodies; * White cell count in cerebrospinal fluid (CSF) \> 5/mm3; * Significant rise in borrelia antibodies in two serum samples collected from a patient with at least 3 weeks interval; * Verified acrodermatitis chronica atrophicans.

Exclusion criteria

* Allergy to the contents in the medication, or earlier type I reaction to penicillin. * Treatment with cephalosporins, penicillin or tetracyclins during the last 14 days * Pregnancy or breastfeeding * Age \< 18 years

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 5, 2026