Metastatic Pancreatic Carcinoma
Conditions
Keywords
Pancreatic Carcinoma, Iressa, Docetaxel
Brief summary
The purpose of this study is to find out what activity the combination of docetaxel and Iressa have against metastatic pancreatic cancer.
Detailed description
Iressa will be taken orally once daily without interruption. Docetaxel will be administered intravenously once weekly for two out of every three weeks. Patients will also receive dexamethasone the night prior, morning of, and the evening after docetaxel treatment to help prevent an allergic reaction. Every week that chemotherapy is given, blood tests and vital signs will be taken. After the first 6 weeks of therapy a CT scan (or other radiological procedure) will be done to assess the progress of the disease. If the cancer is responding to the treatment and no unacceptable side effects have occured, treatment with Iressa and docetaxel will continue. CT scans (or other radiological procedure) will be performed at week 12 and every 9 weeks thereafter to monitor the progress of the disease.
Interventions
DRUGZD 1839
Taken orally once daily
DRUGDocetaxel
Given intravenously once weekly for 2 out of 3 weeks
Sponsors
Massachusetts General Hospital
Beth Israel Deaconess Medical Center
Brigham and Women's Hospital
Dana-Farber Cancer Institute
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Metastatic pancreatic carcinoma (excluding pancreatic endocrine tumors); histologic confirmation of either the primary or metastatic site. * ECOG performance status of \< 1 * \> 4 weeks since completion of previous chemotherapy * \> 4 weeks since participation in any investigational drug study * Peripheral neuropathy of grade \< 1 * Patients must have failed a gemcitabine-containing regimen administered in the metastatic, adjuvant, or locally advanced setting. * Absolute neutrophil count (ANC) \> 1,500/mm3 * Hemoglobin \> 9.0gm/dl * Platelets \> 100,000/mm3 * Total bilirubin \< 2.0mg/dl * AST and alkaline phosphatase \< 5 x upper limit of normal (ULN) * Albumin \> 2.5gm/dl * CA 19-9 \> 1.5 x ULN
Exclusion criteria
* Prior therapy with taxane or with epidermal growth factor receptor (EGFR) inhibitors * More than one prior chemotherapy treatment * Clinically significant cardiac disease * Major surgery within 4 weeks of the start of study treatment * Evidence of central nervous system (CNS) metastases or carcinomatous meningitis or history of uncontrolled seizures, central nervous system disorders. * Uncontrolled serious medical or psychiatric illness * Pregnant or breast-feeding women * Other active malignancy * Inability to swallow tablets or evidence of a gastrointestinal malabsorption syndrome * Known severe hypersensitivity to Iressa * Concomitant use of phenytoin, carbamazepine, barbiturates, rifampicin, phenobarbital, or St. John's wort. * History of severe hypersensitivity reaction to drugs formulated with polysorbate 80 * Any evidence of clinically active interstitial lung disease * Ascites requiring paracentesis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the response rate of Iressa and docetaxel in patients with advanced pancreatic cancer following failure of gemcitabine-based therapy | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| To determine the safety, radiologic response rate, progression-free survival and overall survival of patients treated with Iressa and docetaxel | — |
Countries
United States
Outcome results
None listed