Orthostatic Hypotension
Conditions
Keywords
inspiratory impedance threshold device, blood pressure regulation, head-up tilt test, tilt table testing, burn injury, Burns
Brief summary
This study will see if a special piece of equipment can help burn patients who have been in bed for a long time to get out of bed without feeling dizzy or faint.
Detailed description
To measure stroke volume, cardiac output, arterial blood pressure and cerebral blood flow velocity in human patients while they undergo exposure to head-up tilt that is designed to test their tolerance to an orthostatic challenge.
Interventions
Sponsors
United States Army Institute of Surgical Research
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Military or civilian males or females between the ages of 18-65 years * Burn injury with at least one unburned finger for Portapres measurement * Minimum of 96 hours bedrest or physician directive to tilt
Exclusion criteria
* Age \< 18 and \> 65 years * Facial burns when application of ITD device would cause further trauma * Medical monitoring devices that preclude the use of the ITD * Signs of cardiac abnormalities, autonomic dysfunction * Chronic obstructive pulmonary disease (COPD), or any other respiratory limitations (ventilator dependent, intubated, tracheostomy) limiting use of ITD * History of pre-syncopal/syncopal episodes or orthostatic hypotension * History of atherosclerotic coronary heart disease * Patients taking any kind of cardiovascular pressor medications * Inability to obtain a Portapres pulse wave validated by blood pressure cuff with +/- 5mmHg diastolic blood pressure * Unable to provide informed consent for self
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inspiratory impedance during passive upright tilt will prevent orthostatic hypotension. | 1 hour |
Countries
United States
Outcome results
None listed