Assessment of Voriconazole Penetration Into the Brain by Fluorine-Magnetic Resonance Spectroscopy

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00136968

Enrollment

Registered

2005-08-29

Start date

2005-04-30

Completion date

2005-05-31

Last updated

2009-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fungal Infection

Brief summary

The purpose of this study is to determine the amount of voriconazole in the brain by fluorine-magnetic resonance spectroscopy (MRS) and to compare brain levels to plasma levels.

Interventions

DRUGVoriconazole

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy male volunteers 18-55 years of age

Exclusion criteria

* Subjects with any condition affecting drug absorption * Subjects with a positive urine drug screen

Design outcomes

Primary

Measure	Time frame
Assess brain levels of voriconazole in the brain using a non-evasive technique of MRS	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026