Automated Telephone System to Improve Treatment Adherence in People With Depression

Telecom System to Improve Adherence to Antidepressants

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00136240

Enrollment

144

Registered

2005-08-29

Start date

2003-04-30

Completion date

2006-01-31

Last updated

2013-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Brief summary

This study will determine the efficacy of a computerized telephone system called Telephone-Linked Care (TLC) in improving adherence to antidepressant medication regimens in people with depression.

Detailed description

The purpose of this study is to test the efficacy of a computerized telephone system called TLC (Telephone-Linked Care) in helping subjects adhere to their antidepressant medication regimens.

Interventions

BEHAVIORALComputer Assisted Education for Behavior Change

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* A clinical diagnosis of major depressive disorder, dysthymic disorder, depressive disorder not otherwise specified, or any combination of the three * Prescribed at least one antidepressant medication * Access to a telephone with touch-tone service * Speak and understand conversational English

Exclusion criteria

* Current significant alcohol or drug abuse * Clinical diagnosis of bipolar disorder, schizoaffective disorder, or significant personality disorder * Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), or other neurodegenerative diseases * Alzheimer's disease and other dementia * Cancer, undergoing radiation therapy or chemotherapy * Suffering from Renal disease or on dialysis * Immunologic disorder (rheumatoid arthritis, systemic lupus erythematosus \[SLE\], etc.) * HIV * Terminal illness * Homeless * Legally blind * Planning to leave the geographic area during the study period

Design outcomes

Primary

Measure	Time frame
Antidepressant medication adherence	Measured monthly for 4 months
Adherence to scheduled psychiatry clinic visits	Measured monthly for 4 months

Secondary

Measure	Time frame
Depression status, measured by self-administered depression inventory scale	Measured at baseline and at 4 month follow-up
General health status, measured by self-rating health survey	Measured at baseline and at 4 month follow-up

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026